Shrewsbury, Massachusetts is located Central Massachusetts, bordered by Worcester on the west, Northborough and Westborough on the east, and Grafton on the south and northwest. Shrewsbury is 5 miles east of Worcester, 27 miles south of Fitchburg, 34 miles west of Boston, and 183 miles from New York City. Principal highways are State Route 140 running N-S; and U.S. Route 20 and State Route 9 (the Worcester Turnpike), both cross-state roads. Interstate 290 passes through the northern part of Shrewsbury and forms an interchange with Interstate Route 495, the outer loop around Boston, in the nearby town of Marlborough. Passenger rail service to Boston, Providence, Springfield, and all other points on the Amtrak network is available through neighboring Worcester.

Some information gathered on Shrewsbury, MA is courtesy of Commonwealth Communities at Mass.gov