Mendon, Massachusetts is located Southern Massachusetts, bordered by Bellingham on the east, Blackstone and Millville on the south, Uxbridge and Northbridge on the west, Upton on the northwest, and Hopedale on the north. Mendon is 33 miles southwest of Boston; 28 miles north of Providence, Rhode Island; and 185 miles from New York City. Principal highways are State Routes 16 and 140. There is no freight rail service in Mendon, but the town has easy access to the network of intermodal facilities serving Eastern Massachusetts and Rhode Island.

Some information gathered on Mendon, MA is courtesy of Commonwealth Communities at Mass.gov