Hopkinton, Massachusetts is located Eastern Massachusetts, bordered by Upton on the southwest, Westborough on the northwest, Southborough on the north, Ashland on the northeast, Holliston on the southeast, and Milford on the south. Hopkinton is 17 miles east of Worcester, 26 miles west of Boston, and 195 miles from New York City. Principal highways are State Route 135 and Interstates 90 (the Massachusetts Turnpike) and 495, which form an interchange on the border of Hopkinton and Westborough. There is no passenger or freight rail service in Hopkinton, but the network of intermodal facilities serving Massachusetts is easily accessible.

Some information gathered on Hopkinton, MA is courtesy of Commonwealth Communities at Mass.gov