Hopedale, Massachusetts is located Eastern Massachusetts, bordered by Milford on the northeast, Bellingham on the east, Mendon on the south and west, and Upton on the northwest. Hopedale is 20 miles southeast of Worcester and 31 miles southwest of Boston. Principal highways are State Routes 16 and 140. Interstate 495 is easily accessible in neighboring Milford. There is no freight rail service in Hopedale, but the town has easy access to the network of intermodal facilities serving Eastern Massachusetts and Rhode Island.

Some information gathered on Hopedale, MA is courtesy of Commonwealth Communities at Mass.gov