Carlisle, Massachusetts is located Eastern Massachusetts, bordered by Concord on the south, Acton and Westford on the west, Chelmsford on the north, and Billerica and Bedford on the east. Carlisle is about 11 miles south of Lowell, 20 miles northwest of Boston, 26 miles east of Fitchburg, and 218 miles from New York City. Principal highways are State Route 2 and State Route 225, which runs NW-SE between Interstate Route 495 and State Route 128. There is no passenger or freight rail service in Carlisle, but the network of intermodal facilities serving Massachusetts is easily accessible.

Some information gathered on Carlisle, MA is courtesy of Commonwealth Communities at Mass.gov